The authors present innovative forms and approaches of the Institute of Medical Physics, Biophysics, Informatics and Telemedicine FM CU in Bratislava in the teaching of medical biophysics for medical students for the last five years. Based on the previous content of full-time teaching, theoretical and practical teaching has been modernized and enriched with the physical principles of the latest diagnostic and therapeutic methods used in medical practice. Recently, teaching has been significantly developed using information applications available at Comenius University and e-learning has been fully contentwise ensured.